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	Provedor de dados Genet. Mol. Biol. (2) Autor Cólus,Ilce Mara de Syllos (2) Castro-Gomez,Raul Jorge Hernan (1) D’Arce,Luciana Paula Grégio (1) Gregório,Emerson Pereira (1) Kuasne,Hellen (1) Libos Jr,Farid (1) Losi-Guembarovski,Roberta (1) Magnani,Marciane (1) Mori,Mateus Prates (1) Mais... Palavra-chave Age (1) Antioxidant (1) Brazilian population (1) Carboxymethyl-glucan (1) Control individuals (1) Glutathione S-transferase Mu (GSTM1) (1) Prostate cancer (1) Smoking habit (1) Β-D-glucan (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population Genet. Mol. Biol. Losi-Guembarovski,Roberta; D’Arce,Luciana Paula Grégio; Cólus,Ilce Mara de Syllos. The glutathione S-transferase mu (GSTM1) gene which acts during phase II of xenobiotic metabolism is polymorphic in the population, being absent in about 30-50% of individuals depending on the ethnic group from which they come. Epidemiological studies suggest that individuals who are homozygous null at the GSTM1 locus may have an increased risk of developing various types of neoplastic disease. We used the polymerase chain reaction (PCR) to estimate the frequency of GSTM1 in 176 healthy individuals from the north of Paraná (Brazilian state), the null genotype being detected in 48.86% of these individuals. The Student’s t-test was used to evaluate the frequency of the glutathione S-transferase null genotype in relation to age, gender and smoking habit and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glutathione S-transferase Mu (GSTM1); Control individuals; Brazilian population; Age; Smoking habit. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000400001 Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer Genet. Mol. Biol. Magnani,Marciane; Castro-Gomez,Raul Jorge Hernan; Mori,Mateus Prates; Kuasne,Hellen; Gregório,Emerson Pereira; Libos Jr,Farid; Cólus,Ilce Mara de Syllos. Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidant; Β-D-glucan; Carboxymethyl-glucan; Prostate cancer. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100023 Registros recuperados: 2 Primeira ... 1 ... Última

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